Only those individuals who have taken at least one dose of COVID-19 vaccination approved by WHO can apply for TCS World 10K 2022; a vaccination certificate certifying the same must be uploaded while applying for the race. Participation in TCS World 10K Bengaluru 2022 will be confirmed only where the participant is fully vaccinated (WHO approved vaccines) by 30th April 2022, and he/she uploads the said certificate either at the time of registration or by 11:59 p.m. IST on 30th April 2022 on the ‘my profile’ section of the TCS World 10K website. Such confirmed participants can collect their running number bibs from the Get Active Mirchi 2022 Expo (12th to 14th May 2022).

On race day, each participant's temperature will be thermally screened, and those with fever or who are ill, will not be allowed to run on race day – participants will be asked to leave the race premises with immediate effect.